Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

MLN4924: a novel first-in-class inhibitor of NEDD8-activating enzyme for cancer therapy

16 Jul 2012

Abstract excerpt

INTRODUCTION: The small ubiquitin-like molecule NEDD8 has been identified as an essential regulator of the activity of the cullin-RING E3 ubiquitin ligases (CRLs), which control the turnover of multiple proteins with fundamental roles in cancer biology. The aberrant function of the NEDD8 cascade within the context of malignancy makes it an attractive target for the development of novel anticancer agents. MLN4924...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Adhesion Molecules Research
Share to Peptidase Inhibition and Analysis
Share to Ubiquitin and proteasome pathways

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22799561
DOI: 10.1517/13543784.2012.707192

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

MLN4924: a novel first-in-class inhibitor of NEDD8-activating enzyme for cancer therapyPMID 22799561Read ↗

Targeting cullin neddylation for cancer and fibrotic diseasesSemantic proximity Read ↗

Targeting protein neddylation: a novel therapeutic strategy for the treatment of cancerSemantic proximity Read ↗

The NEDD8 Conjugation Pathway and Its Relevance in Cancer Biology and TherapySemantic proximity Read ↗

Targeting NEDD8-Activated Cullin-RING Ligases for the Treatment of CancerSemantic proximity Read ↗

Unraveling the Potential Role of NEDD4-like E3 Ligases in CancerSemantic proximity Read ↗

Targeted inhibition of the COP9 signalosome for treatment of cancerSemantic proximity Read ↗

NEDD4 E3 ubiquitin ligases: Promising biomarkers and therapeutic targets for cancerSemantic proximity Read ↗

NEDD4 E3 ligase: Functions and mechanism in human cancerSemantic proximity Read ↗

Discovery of WS-384, a first-in-class dual LSD1 and DCN1-UBC12 protein-protein interaction inhibitor for the treatment of non-small cell lung cancer (NSCLC)Semantic proximity Read ↗

Preclinical and clinical studies of the NEDD9 scaffold protein in cancer and other diseasesSemantic proximity Read ↗

The Protein Neddylation Inhibitor MLN4924 Suppresses Patient-Derived Glioblastoma Cells via Inhibition of ERK and AKT SignalingSemantic proximity Read ↗

Targeting oncogenic K-Ras mutants with a small-molecule degrader through Nedd4-1Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.