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Targeting cullin neddylation for cancer and fibrotic diseases

1 Jan 2023

Abstract excerpt

Protein neddylation is a post-translational modification, and its best recognized substrates are cullin family proteins, which are the core component of Cullin-RING ligases (CRLs). Given that most neddylation pathway proteins are overactivated in different cancers and fibrotic diseases, targeting neddylation becomes an emerging approach for the treatment of these diseases. To date, numerous neddylation inhibitors...

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PMID: 37771770
DOI: 10.7150/thno.78876

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