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Article

A Functional Variant rs3093023 in CCR6 Is Associated With IgA Nephropathy by Regulating Th17 Cells in a North Han Chinese Population.

Frontiers in immunology - 1 Jan 2021

Zhang Yue-Miao, Liu Xing-Zi, Zhou Xu-Jie, Liu Li-Jun, Shi Su-Fang, Hou Ping, Lv Ji-Cheng, Zhang Hong

Abstract excerpt

C-C chemokine receptor 6 (CCR6) is a susceptibility gene of various immune-related diseases, which was suggested to be shared with immunoglobulin A nephropathy (IgAN). In this study, we aimed to identify the functional variants. First, we analyzed the associations of CCR6 common and rare variants detected by multi-platform chips with IgAN susceptibility using imputation and identified 68 significantly associated...

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Identifiers

PMID: 33717080
DOI: 10.3389/fimmu.2021.600598
PMCID: PMC7946973

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