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Article

DEFA gene variants associated with IgA nephropathy in a Chinese population.

Genes and immunity - 1 Jan 2000

Qi Y Y, Zhou X J, Cheng F J, Hou P, Zhu L, Shi S F, Liu L J, Lv J C, Zhang H

Abstract excerpt

IgA nephropathy (IgAN) is a complex syndrome with high genetic heterogeneity. More recently, a genome-wide association study (GWAS) from Southern Han population revealed that variants within 8p23.1, where the DEFA genes encoding a-defensins assembled, were associated with susceptibility to IgAN. To replicate the association and fine-map the genetic variants, a case-control genetic study from an independent...

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PMID: 25675412
DOI: 10.1038/gene.2015.1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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