Polymorphism of DEFA in Chinese Han population with IgA nephropathy.

doi:10.1007/s00439-014-1464-y

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Article

Polymorphism of DEFA in Chinese Han population with IgA nephropathy.

Human genetics - 1 Oct 2014

Xu Ricong, Feng Shaozhen, Li Zhijian, Fu Yonggui, Yin Peiran, Ai Zhen, Liu Wenting, Yu Xueqing, Li Ming

Abstract excerpt

Our recent genome-wide association study (GWAS) had discovered a new locus at 8p23 (rs2738048) associated with IgA nephropathy (IgAN) in Chinese Han patients, implicating the DEFA gene family within this locus as susceptibility genes. However, it is still unknown whether there are additional variations within these genes associated with the disease susceptibility. The aim of this study is to investigate the...

Topics

Adult
Asian People
Case-Control Studies
Female
Gene Frequency
Genetic Predisposition to Disease
Genome-Wide Association Study
Glomerulonephritis, IGA
HEK293 Cells
Humans
Linkage Disequilibrium
Male
Multigene Family
Polymorphism, Single Nucleotide
alpha-Defensins

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Open in PubMed

Identifiers

PMID: 25024040
DOI: 10.1007/s00439-014-1464-y

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