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Triple-Negative Breast Cancer: Intact Mismatch Repair and Partial Co-Expression of PD-L1 and LAG-3

24 Feb 2021

Abstract excerpt

Background and Aim: Poor response to immune checkpoint inhibitors (ICIs) has been observed in most triple-negative breast cancer (TNBC) cases (around 80%). Our aim was to investigate the status of mismatch repair (MMR), microsatellite instability (MSI), programmed death-ligand 1 (PD-L1), and lymphocyte-activation gene 3 (LAG-3) in TNBC. Methods: A total of 74 TNBC samples were retrospectively analyzed. MMR and...

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Identifiers

PMID: 33717059
DOI: 10.3389/fimmu.2021.561793

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