Article
An immune stratification reveals a subset of PD-1/LAG-3 double-positive triple-negative breast cancers.
Breast cancer research : BCR - 3 Dec 2016
Bottai Giulia, Raschioni Carlotta, Losurdo Agnese, Di Tommaso Luca, Tinterri Corrado, Torrisi Rosalba, Reis-Filho Jorge S, Roncalli Massimo, Sotiriou Christos, Santoro Armando, Mantovani Alberto, Loi Sherene, Santarpia Libero
Abstract excerpt
BACKGROUND: Stromal tumor-infiltrating lymphocytes (TILs) are a robust prognostic factor in triple-negative breast cancer (TNBC). However, the clinical significance of TILs may be influenced by the complex landscape of the tumor immune microenvironment. In this study, we aimed to evaluate the composition and the functionality of lymphocytic infiltration and checkpoint receptors in TNBC. METHODS: Formalin-fixed,...
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