Genome-wide association study of asthma, total IgE, and lung function in a cohort of Peruvian children.

doi:10.1016/j.jaci.2021.02.035

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Article

Genome-wide association study of asthma, total IgE, and lung function in a cohort of Peruvian children.

The Journal of allergy and clinical immunology - 1 Dec 2021

Akenroye Ayobami T, Brunetti Tonya, Romero Karina, Daya Michelle, Kanchan Kanika, Shankar Gautam, Chavan Sameer, Preethi Boorgula Meher, Ampleford Elizabeth A, Fonseca Héllen Freitas, Hawkins Gregory A, Pitangueira Teixeira Helena Mariana, Campbell Monica, Rafaels Nicholas, Winters Alexandra, Bleecker Eugene R, Cruz Alvaro A, Barreto Mauricio L, Meyers Deborah A, Ortega Victor E, Figueiredo Camila A, Barnes Kathleen C, Checkley William, Hansel Nadia N, Mathias Rasika A

Abstract excerpt

BACKGROUND: Genetic ancestry plays a role in asthma health disparities. OBJECTIVE: Our aim was to evaluate the impact of ancestry on and identify genetic variants associated with asthma, total serum IgE level, and lung function. METHODS: A total of 436 Peruvian children (aged 9-19 years) with asthma and 291 without asthma were genotyped by using the Illumina Multi-Ethnic Global Array. Genome-wide proportions of...

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PMID: 33713768
DOI: 10.1016/j.jaci.2021.02.035
PMCID: PMC8429514

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