Article
FGF20 and PGM2 variants are associated with childhood asthma in family-based whole-genome sequencing studies.
Human molecular genetics - 27 Jan 2023
Hecker Julian, Chun Sung, Samiei Ahmad, Liu Cuining, Laurie Cecelia, Kachroo Priyadarshini, Lutz Sharon M, Lee Sanghun, Smith Albert V, Lasky-Su Jessica, Cho Michael H, Sharma Sunita, Soto Quirós Manuel Enrique, Avila Lydiana, Celedón Juan C, Raby Benjamin, Zhou Xiaobo, Silverman Edwin K, DeMeo Dawn L, Lange Christoph, Weiss Scott T
Abstract excerpt
BACKGROUND: Asthma is a heterogeneous common respiratory disease that remains poorly understood. The established genetic associations fail to explain the high estimated heritability, and the prevalence of asthma differs between populations and geographic regions. Robust association analyses incorporating different genetic ancestries and whole-genome sequencing data may identify novel genetic associations....
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