Article
Genome-wide association study and admixture mapping identify different asthma-associated loci in Latinos: the Genes-environments & Admixture in Latino Americans study.
The Journal of allergy and clinical immunology - 1 Aug 2014
Galanter Joshua M, Gignoux Christopher R, Torgerson Dara G, Roth Lindsey A, Eng Celeste, Oh Sam S, Nguyen Elizabeth A, Drake Katherine A, Huntsman Scott, Hu Donglei, Sen Saunak, Davis Adam, Farber Harold J, Avila Pedro C, Brigino-Buenaventura Emerita, LeNoir Michael A, Meade Kelley, Serebrisky Denise, Borrell Luisa N, Rodríguez-Cintrón William, Estrada Andres Moreno, Mendoza Karla Sandoval, Winkler Cheryl A, Klitz William, Romieu Isabelle, London Stephanie J, Gilliland Frank, Martinez Fernando, Bustamante Carlos, Williams L Keoki, Kumar Rajesh, Rodríguez-Santana José R, Burchard Esteban G
Abstract excerpt
BACKGROUND: Asthma is a complex disease with both genetic and environmental causes. Genome-wide association studies of asthma have mostly involved European populations, and replication of positive associations has been inconsistent. OBJECTIVE: We sought to identify asthma-associated genes in a large Latino population with genome-wide association analysis and admixture mapping. METHODS: Latino children with asthma...
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