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Glutamate metabolism is impaired in transgenic mice with tau hyperphosphorylation.

Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism - 1 May 2013

Nilsen Linn Hege, Rae Caroline, Ittner Lars M, Götz Jürgen, Sonnewald Ursula

Abstract excerpt

In neurodegenerative diseases including Alzheimer's disease and frontotemporal dementia, the protein tau is hyperphosphorylated and eventually aggregates to develop neurofibrillary tangles. Here, the consequences of tau hyperphosphorylation on both neuronal and astrocytic metabolism and amino-acid neurotransmitter homeostasis were assessed in transgenic mice expressing the pathogenic mutation P301L in the human...

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Identifiers

PMID: 23340677
DOI: 10.1038/jcbfm.2012.212
PMCID: PMC3652703

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