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Article

The functional polymorphisms linked with interleukin-1β gene expression are associated with bipolar disorder.

Psychiatric genetics - 1 Apr 2021

Pu Xingfu, Li Jianghui, Ma Xiaoyuan, Yang Shunying, Wang Libo

Abstract excerpt

BACKGROUND: Bipolar disorder (BD) is a severe psychiatric illness attributable to multifactorial risk components (e.g. environmental stimuli, neuroinflammation, etc.), and genetic variations affecting these risk components are considered pivotal predisposing factors. The interleukin-1β (IL-1β) gene and its protein product have been repeatedly highlighted in the pathogenesis of BD. As functional polymorphisms and...

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PMID: 33707400
DOI: 10.1097/YPG.0000000000000272

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