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Article

Effects of interleukin-1beta polymorphisms on brain function and behavior in healthy and psychiatric disease conditions.

Cytokine & growth factor reviews - 1 Oct 2017

Tsai Shih-Jen

Abstract excerpt

A high level of Interleukin-1beta (IL1B), a key mediator of inflammation, is expressed in the brain, particularly in the hippocampus, which plays a pivotal role in memory and mood regulation. In the brain, IL1B exerts a myriad of effects such as neuronal proliferation, differentiation, apoptosis, and long-term potentiation. Considering its pleiotropic effects in the brain, IL1B has been implicated in the...

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Identifiers

PMID: 28599834
DOI: 10.1016/j.cytogfr.2017.06.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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