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Article

A Study on the Association of Interleukin-1 Cluster with Genetic Risk in Bipolar I Disorder in Iranian Patients: A Case-control Study.

Iranian journal of allergy, asthma, and immunology - 1 Dec 2016

Talaei Ali, Tavakkol Afshari Jalil, Fayyazi Bordbar Mohammad Reza, Pouryousof Hamidreza, Faridhosseini Farhad, Saghebi Ali, Rezaei Ardani Amir, Talaei Andisheh, Tehrani Mohsen

Abstract excerpt

The pathogenesis of Bipolar I Disorder (BP-I) involves immune-mediated mechanisms, especially an imbalance in pro-inflammatory/anti-inflammatory cytokines in plasma or cerebrospinal fluid. Interleukin-1 (IL-1) gene cluster, coding some of these pro-inflammatory cytokines, might play a role in various neuropathologies related to neuron inflammation. The aim of the present study was to investigate the possible role...

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PMID: 28129679

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