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Airway Epithelium Senescence as a Driving Mechanism in COPD Pathogenesis

23 Jul 2023

Abstract excerpt

Cellular senescence is a state of permanent cell cycle arrest triggered by various intrinsic and extrinsic stressors. Cellular senescence results in impaired tissue repair and remodeling, loss of physiological integrity, organ dysfunction, and changes in the secretome. The systemic accumulation of senescence cells has been observed in many age-related diseases. Likewise, cellular senescence has been implicated as...

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PMID: 37509711
DOI: 10.3390/biomedicines11072072

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