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Article

The dimeric Golgi protein Gorab binds to Sas6 as a monomer to mediate centriole duplication.

eLife - 11 Mar 2021

Fatalska Agnieszka, Stepinac Emma, Richter Magdalena, Kovacs Levente, Pietras Zbigniew, Puchinger Martin, Dong Gang, Dadlez Michal, Glover David M

Abstract excerpt

The duplication and ninefold symmetry of the Drosophila centriole requires that the cartwheel molecule, Sas6, physically associates with Gorab, a trans-Golgi component. How Gorab achieves these disparate associations is unclear. Here, we use hydrogen-deuterium exchange mass spectrometry to define Gorab's interacting surfaces that mediate its subcellular localization. We identify a core stabilization sequence...

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Identifiers

PMID: 33704067
DOI: 10.7554/eLife.57241
PMCID: PMC8009671

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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