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Article

Interleukin-6 produced by enteric neurons regulates the number and phenotype of microbe-responsive regulatory T cells in the gut.

Immunity - 9 Mar 2021

Yan Yiqing, Ramanan Deepshika, Rozenberg Milena, McGovern Kelly, Rastelli Daniella, Vijaykumar Brinda, Yaghi Omar, Voisin Tiphaine, Mosaheb Munir, Chiu Isaac, Itzkovitz Shalev, Rao Meenakshi, Mathis Diane, Benoist Christophe

Abstract excerpt

The immune and enteric nervous (ENS) systems monitor the frontier with commensal and pathogenic microbes in the colon. We investigated whether FoxP3+ regulatory T (Treg) cells functionally interact with the ENS. Indeed, microbe-responsive RORγ+ and Helios+ subsets localized in close apposition to nitrergic and peptidergic nerve fibers in the colon lamina propria (LP). Enteric neurons inhibited in vitro Treg...

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Identifiers

PMID: 33691135
DOI: 10.1016/j.immuni.2021.02.002
PMCID: PMC8133394

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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