Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Congenital heart disease and folate pathway gene polymorphisms: findings from a North Indian cohort.

BMC cardiovascular disorders - 17 Jan 2026

Kukshal Prachi, Ahamad Shadab, Joshi Radha, Kumar Ajay, Chellappan Subramanian

Abstract excerpt

BACKGROUND: Folate plays a critical role in DNA synthesis, fetal development, and epigenomic regulation and its deficiencies can lead to several health defects, including adverse pregnancy outcomes and congenital heart defects (CHDs). Folic acid supplementation represents a low-cost, high-impact preventive strategy in maternal and child health, with particular relevance for underserved and high-risk populations....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase
Share to Folic Acid

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Heart Defects, Congenital

Share to Methylenetetrahydrofolate Dehydrogenase (NADP)

Share to Methylenetetrahydrofolate Reductase (NADPH2)

Share to Minor Histocompatibility Antigens

Share to Nutritional Status

Source

Open in PubMed Open full text

Identifiers

PMID: 41545838
DOI: 10.1186/s12872-025-05194-6
PMCID: PMC12895914

Genes

MTHFR
MTHFD1
MTR
TCN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Congenital heart disease and folate pathway gene polymorphisms: findings from a North Indian cohort.PMID 41545838Read ↗

Congenital Heart Disease and Genetic Changes in Folate/Methionine Cycles.Semantic proximity Read ↗

Association of Maternal Folate Intake and Offspring MTHFD1 and MTHFD2 Genes with Congenital Heart DiseaseSemantic proximity Read ↗

Genetic polymorphisms in MTR are associated with non-syndromic congenital heart disease from a family-based case-control study in the Chinese populationSemantic proximity Read ↗

Periconception Red Blood Cell Folate and Offspring Congenital Heart DiseaseSemantic proximity Read ↗

Association of maternal methionine synthase reductase gene polymorphisms with the risk of congenital heart disease in offspring: a hospital-based case-control study.Semantic proximity Read ↗

Association of maternal folic acid supplementation and offspring MTRR gene polymorphism with congenital heart disease: a hospital-based case-control study in Han populationSemantic proximity Read ↗

Variants of folate metabolism genes and the risk of conotruncal cardiac defects.Semantic proximity Read ↗

Association of maternal folic acid supplementation and offspring MTRR gene polymorphism with congenital heart disease: a hospital-based case-control study in Han population.Semantic proximity Read ↗

Association of SNPs in genes involved in folate metabolism with the risk of congenital heart disease.Semantic proximity Read ↗

Study on Environmental Causes and SNPs of MTHFR, MS and CBS Genes Related to Congenital Heart Disease.Semantic proximity Read ↗

[Case-control study on the association between four single nucleotide polymorphisms in folate metabolism way and the risk of congenital heart disease].Semantic proximity Read ↗

Maternal MTHFR A1298C polymorphism and risk of congenital heart disease in fetusSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.