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Article

Obstructive heart defects associated with candidate genes, maternal obesity, and folic acid supplementation.

American journal of medical genetics. Part A - 1 Jun 2015

Tang Xinyu, Cleves Mario A, Nick Todd G, Li Ming, MacLeod Stewart L, Erickson Stephen W, Li Jingyun, Shaw Gary M, Mosley Bridget S, Hobbs Charlotte A

Abstract excerpt

Right-sided and left-sided obstructive heart defects (OHDs) are subtypes of congenital heart defects, in which the heart valves, arteries, or veins are abnormally narrow or blocked. Previous studies have suggested that the development of OHDs involved a complex interplay between genetic variants and maternal factors. Using the data from 569 OHD case families and 1,644 control families enrolled in the National...

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Source

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Identifiers

PMID: 25846410
DOI: 10.1002/ajmg.a.36867
PMCID: PMC4675451

Genes

BHMT
BHMT2
GCLC
MTHFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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