Article
Regulation of blood pressure and renal electrolyte balance by Cullin-RING ligases.
Current opinion in nephrology and hypertension - 1 Sept 2014
Uchida Shinichi
Abstract excerpt
PURPOSE OF REVIEW: Efforts to explore the pathogenic mechanisms underlying hereditary hypertension caused by a single gene mutation have brought about conceptual advances in our understanding of blood pressure regulation. We here discuss a novel pathogenic mechanism underlying the hereditary hypertensive disease pseudohypoaldosteronism type II (PHAII), caused by mutations in three different genes encoding for...
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