Article

Evidence for Functional Regulation of the KLHL3/WNK Pathway by O-GlcNAcylation

2025-02-27

Abstract excerpt

The 42-member Kelch-like (KLHL) protein family are adaptors for ubiquitin E3 ligase complexes, governing the stability of a wide range of substrates. KLHL proteins are critical for maintaining proteostasis in a variety of tissues and are mutated in human diseases, including cancer, neurodegeneration, and familial hyperkalemic hypertension. However, the regulation of KLHL proteins remains incompletely understood. P...

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Literature Corpus work: 88ed7366-539b-5001-aa71-5df9bd6bde3a
DOI: 10.1101/2025.02.27.640596

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Evidence for Functional Regulation of the KLHL3/WNK Pathway by O-GlcNAcylationDOI 10.1101/2025.02.27.640596Read

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