Article
Kelch-like 3 and Cullin 3 regulate electrolyte homeostasis via ubiquitination and degradation of WNK4.
Proceedings of the National Academy of Sciences of the United States of America - 7 May 2013
Shibata Shigeru, Zhang Junhui, Puthumana Jeremy, Stone Kathryn L, Lifton Richard P
Abstract excerpt
Pseudohypoaldosteronism type II (PHAII) is a rare Mendelian syndrome featuring hypertension and hyperkalemia resulting from constitutive renal salt reabsorption and impaired K(+) secretion. Recently, mutations in Kelch-like 3 (KLHL3) and Cullin 3 (CUL3), components of an E3 ubiquitin ligase complex, were found to cause PHAII, suggesting that loss of this complex's ability to target specific substrates for...
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