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Article

Regulation of the renal NaCl cotransporter by the WNK/SPAK pathway: lessons learned from genetically altered animals.

American journal of physiology. Renal physiology - 1 Jan 2019

Ostrosky-Frid Mauricio, Castañeda-Bueno María, Gamba Gerardo

Abstract excerpt

The renal thiazide-sensitive NaCl cotransporter (NCC) is the major salt transport pathway in the distal convoluted tubule of the mammalian nephron. NCC activity is critical for modulation of arterial blood pressure and serum potassium levels. Reduced activity of NCC in genetic diseases results in arterial hypotension and hypokalemia, while increased activity results in genetic diseases featuring hypertension and...

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Source

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Identifiers

PMID: 30089030
DOI: 10.1152/ajprenal.00288.2018
PMCID: PMC6383199

Genes

CUL3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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