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Pretangles and neurofibrillary changes: Similarities and differences between AD and CBD based on molecular and morphological evolution

26 Feb 2014

Abstract excerpt

Pretangles are cytoplasmic tau immunoreactivity in neurons without apparent formation of fibrillary structures. In Alzheimer disease, such tau deposition is considered to represent a premature state prior to fibril formation (AD-pretangles), later to form neurofibrillary tangles and finally ghost tangles. This morphological evolution from pretangles to ghost tangles is in parallel with their profile shift from...

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PMID: 24612177
DOI: 10.1111/neup.12108

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