Article
Abnormal sperm in mice lacking the Taf7l gene.
Molecular and cellular biology - 1 Apr 2007
Cheng Yong, Buffone Mariano G, Kouadio Martin, Goodheart Mary, Page David C, Gerton George L, Davidson Irwin, Wang Peijing Jeremy
Abstract excerpt
TFIID is a general transcription factor required for transcription of most protein-coding genes by RNA polymerase II. TAF7L is an X-linked germ cell-specific paralogue of TAF7, which is a generally expressed component of TFIID. Here, we report the generation of Taf7l mutant mice by homologous recombination in embryonic stem cells by using the Cre-loxP strategy. While spermatogenesis was completed in Taf7l(-/Y)...
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