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Article

CRISPR-based knock-in mutagenesis of the pioneer transcription factor FOXA1: optimization of strategies for multi-allelic proteins in cancer cells.

FEBS open bio - 1 Jun 2021

Li Shen, Garay Joseph P, Tubbs Colby A, Franco Hector L

Abstract excerpt

Precise genome engineering of living cells has been revolutionized by the introduction of the highly specific and easily programmable properties of the clustered regularly interspaced short palindromic repeats (CRISPR) technology. This has greatly accelerated research into human health and has facilitated the discovery of novel therapeutics. CRISPR-Cas9 is most widely employed for its ability to inactivate or...

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Identifiers

PMID: 33666335
DOI: 10.1002/2211-5463.13139
PMCID: PMC8167868

Genes

FOXA1

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