Article
Pig-a gene mutations in bone marrow granulocytes of procarbazine-treated F344 rats.
Environmental and molecular mutagenesis - 1 Apr 2021
Dad Azra, Revollo Javier R, Pearce Mason G, McKinzie Page B, Heflich Robert H, Dobrovolsky Vasily N
Abstract excerpt
It was previously demonstrated that procarbazine (PCZ) is positive in the rat erythrocyte Pig-a gene mutation assay. However, since mammalian erythrocytes lack genomic DNA, it was necessary to analyze nucleated bone-marrow erythroid precursor cells to confirm that PCZ induces mutations in the Pig-a gene (Revollo et al., Environ Mol Mutagen, 2020). In this study, the association between Pig-a mutation and loss of...
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