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Spectrum of Pig-a mutations in T lymphocytes of rats treated with procarbazine.

Mutagenesis - 31 Dec 2017

Revollo Javier, Bhalli Javed A, Tebbe Cameron, Noteboom Jessica, Thomas Demetria, McKinzie Page, Felton Nicholas, Pearce Mason G, Dobrovolsky Vasily N

Abstract excerpt

Procarbazine is a primary component of antineoplastic combination chemotherapy often used for the treatment of Hodgkin's lymphoma. It is believed that cytostatic and cytotoxic properties of procarbazine are mediated via its interaction with genomic DNA. Procarbazine is a carcinogen in animal models; it is classified as Group 2A compound by IARC. Also it is known as an in vitro and in vivo mutagen and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 29237063
DOI: 10.1093/mutage/gex032

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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