Article
GSTM1 and GSTT1 polymorphisms in healthy volunteers - a worldwide systematic review.
Drug metabolism reviews - 1 Feb 2022
Nakanishi Giovana, Bertagnolli Laísa S, Pita-Oliveira Murilo, Scudeler Mariana M, Torres-Loureiro Sabrina, Almeida-Dantas Thaís, Alves Maria Laura C, Cirino Heithor S, Rodrigues-Soares Fernanda
Abstract excerpt
The GSTM1 and GSTT1 genes encode homonymous enzymes, which are responsible for the detoxification of several substances potentially harmful to the human body, such as air pollution, drugs, pesticides, and tobacco. However, some individuals may present a complete deletion of these genes and, consequently, an enzyme deficiency leading to an inadequate metabolism and, therefore, a higher susceptibility to some...
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