Article
Inter- and intra-tumor heterogeneity of metastatic prostate cancer determined by digital spatial gene expression profiling.
Nature communications - 3 Mar 2021
Brady Lauren, Kriner Michelle, Coleman Ilsa, Morrissey Colm, Roudier Martine, True Lawrence D, Gulati Roman, Plymate Stephen R, Zhou Zoey, Birditt Brian, Meredith Rhonda, Geiss Gary, Hoang Margaret, Beechem Joseph, Nelson Peter S
Abstract excerpt
Metastatic prostate cancer (mPC) comprises a spectrum of diverse phenotypes. However, the extent of inter- and intra-tumor heterogeneity is not established. Here we use digital spatial profiling (DSP) technology to quantitate transcript and protein abundance in spatially-distinct regions of mPCs. By assessing multiple discrete areas across multiple metastases, we find a high level of intra-patient homogeneity...
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