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Article

Uncovering phenotypic heterogeneity through research autopsy in lethal prostate cancer.

The Journal of clinical investigation - 1 Aug 2025

Chan Sylvie Sw, Vainauskas Osvaldas, Attard Gerhardt

Abstract excerpt

Tumor heterogeneity in metastatic prostate cancer (mPC) is well established, but comprehensive characterization using routine sampling remains challenging. Autopsy-based research addresses this obstacle by enabling broad tissue collection within individual patients after treatment. In this issue of the JCI, Roudier et al. analyzed samples from a mPC research autopsy cohort, revealing extensive inter- and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40759566
DOI: 10.1172/JCI195102
PMCID: PMC12321379

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