Article

High-resolution multiplexed antibody-omics and interpretable machine learning unveil novel pathogenic mechanisms in kidney transplant rejection

2025-07-27

Abstract excerpt

Antibody-mediated rejection (AbMR), driven by donor-specific alloantibodies (DSAs), is a major cause of late-stage kidney allograft failure, leading to premature graft loss in over half of affected patients. Despite efforts to link DSA features (e.g., HLA-specific IgG titers) to rejection risk, the immune mechanisms distinguishing DSA+ patients who develop AbMR remain unclear. In this first-in-class study, we deve...

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Literature Corpus work: e4f825a4-c64f-5c10-86c0-19c5916210d0
DOI: 10.1101/2025.07.25.25332230

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