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Genetics and epigenetics of aging and longevity

6 Mar 2014

Abstract excerpt

Evolutionary theories of aging predict the existence of certain genes that provide selective advantage early in life with adverse effect on lifespan later in life (antagonistic pleiotropy theory) or longevity insurance genes (disposable soma theory). Indeed, the study of human and animal genetics is gradually identifying new genes that increase lifespan when overexpressed or mutated: gerontogenes. Furthermore,...

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PMID: 24603410
DOI: 10.4161/cc.28433

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