Article
Sex Differences in Genetic Associations With Longevity.
JAMA network open - 1 Aug 2018
Zeng Yi, Nie Chao, Min Junxia, Chen Huashuai, Liu Xiaomin, Ye Rui, Chen Zhihua, Bai Chen, Xie Enjun, Yin Zhaoxue, Lv Yuebin, Lu Jiehua, Li Jianxin, Ni Ting, Bolund Lars, Land Kenneth C, Yashin Anatoliy, O'Rand Angela M, Sun Liang, Yang Ze, Tao Wei, Gurinovich Anastasia, Franceschi Claudio, Xie Jichun, Gu Jun, Hou Yong, Liu Xiao, Xu Xun, Robine Jean-Marie, Deelen Joris, Sebastiani Paola, Slagboom Eline, Perls Thomas, Hauser Elizabeth, Gottschalk William, Tan Qihua, Christensen Kaare, Shi Xiaoming, Lutz Mike, Tian Xiao-Li, Yang Huanming, Vaupel James
Abstract excerpt
IMPORTANCE: Sex differences in genetic associations with human longevity remain largely unknown; investigations on this topic are important for individualized health care. OBJECTIVE: To explore sex differences in genetic associations with longevity. DESIGN SETTING AND PARTICIPANTS: This population-based case-control study used sex-specific genome-wide association study and polygenic risk score (PRS) analyses to...
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