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Article

Association between Smoking History and Tumor Mutation Burden in Advanced Non-Small Cell Lung Cancer.

Cancer research - 1 May 2021

Wang Xinan, Ricciuti Biagio, Nguyen Tom, Li Xihao, Rabin Michael S, Awad Mark M, Lin Xihong, Johnson Bruce E, Christiani David C

Abstract excerpt

Lung carcinogenesis is a complex and stepwise process involving accumulation of genetic mutations in signaling and oncogenic pathways via interactions with environmental factors and host susceptibility. Tobacco exposure is the leading cause of lung cancer, but its relationship to clinically relevant mutations and the composite tumor mutation burden (TMB) has not been fully elucidated. In this study, we...

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Identifiers

PMID: 33653773
DOI: 10.1158/0008-5472.CAN-20-3991
PMCID: PMC8137661

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