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Clinical and Molecular Correlates of Tumor Mutation Burden in Non-Small Cell Lung Cancer.

Lung cancer (Amsterdam, Netherlands) - 1 Aug 2020

Sharpnack Michael F, Cho Ju Hwan, Johnson Travis S, Otterson Gregory A, Shields Peter G, Huang Kun, Carbone David P, He Kai

Abstract excerpt

INTRODUCTION: Recent clinical studies have identified tumor mutation burden (TMB) as a promising therapeutic biomarker of anti-tumor immune checkpoint blockade. However, given the relatively slow turnaround time and high expense in measuring TMB, tobacco smoking history (TSH) is an attractive replacement biomarker. The carcinogenic effects of tobacco smoking may be modified by the protective effects of genome...

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PMID: 32505734
DOI: 10.1016/j.lungcan.2020.05.021

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