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Article

Common driver mutations and smoking history affect tumor mutation burden in lung adenocarcinoma.

The Journal of surgical research - 1 Oct 2018

Nagahashi Masayuki, Sato Seijiro, Yuza Kizuki, Shimada Yoshifumi, Ichikawa Hiroshi, Watanabe Satoshi, Takada Kazuki, Okamoto Tatsuro, Okuda Shujiro, Lyle Stephen, Takabe Kazuaki, Tsuchida Masanori, Wakai Toshifumi

Abstract excerpt

BACKGROUND: Recent progress in genomic analysis using next-generation sequencing technology has enabled the comprehensive detection of mutations and tumor mutation burden (TMB) in patients. A high TMB (TMB-H) tumor is defined as one with high somatic mutational rates, which correlates with clinical responses to certain treatments such as immunotherapies. We determined TMB in lung adenocarcinoma and clarified the...

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Identifiers

PMID: 30072189
DOI: 10.1016/j.jss.2018.07.007
PMCID: PMC10389245

Genes

ALK
EGFR
ERBB2
MET
RET

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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