Article
Factor H Autoantibodies and Complement-Mediated Diseases.
Frontiers in immunology - 1 Jan 2020
Zhang Yuzhou, Ghiringhelli Borsa Nicolo, Shao Dingwu, Dopler Arthur, Jones Michael B, Meyer Nicole C, Pitcher Gabriella R, Taylor Amanda O, Nester Carla M, Schmidt Christoph Q, Smith Richard J H
Abstract excerpt
Factor H (FH), a member of the regulators-of-complement-activation (RCA) family of proteins, circulates in human plasma at concentrations of 180-420 mg/L where it controls the alternative pathway (AP) of complement in the fluid phase and on cell surfaces. When the regulatory function of FH is impaired, complement-mediated tissue injury and inflammation occur, leading to diseases such as atypical hemolytic uremic...
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