Article
Deregulation of Factor H by Factor H-Related Protein 1 Depends on Sialylation of Host Surfaces.
Frontiers in immunology - 1 Jan 2021
Dopler Arthur, Stibitzky Selina, Hevey Rachel, Mannes Marco, Guariento Mara, Höchsmann Britta, Schrezenmeier Hubert, Ricklin Daniel, Schmidt Christoph Q
Abstract excerpt
To discriminate between self and non-self surfaces and facilitate immune surveillance, the complement system relies on the interplay between surface-directed activators and regulators. The dimeric modulator FHR-1 is hypothesized to competitively remove the complement regulator FH from surfaces that strongly fix opsonic C3b molecules-a process known as "deregulation." The C-terminal regions of FH and FHR-1 provide...
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