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Article

IL-3 and CTLA4 gene polymorphisms may influence the tacrolimus dose requirement in Chinese kidney transplant recipients.

Acta pharmacologica Sinica - 1 Mar 2017

Liu Mou-Ze, He Hai-Yan, Zhang Yue-Li, Hu Yong-Fang, He Fa-Zhong, Luo Jian-Quan, Luo Zhi-Ying, Chen Xiao-Ping, Liu Zhao-Qian, Zhou Hong-Hao, Shao Ming-Jie, Ming Ying-Zi, Xin Hua-Wen, Zhang Wei

Abstract excerpt

The highly variable pharmacokinetics and narrow therapeutic window of tacrolimus (TAC) has hampered its clinical use. Genetic polymorphisms may contribute to the variable response, but the evidence is not compelling, and the explanation is unclear. In this study we attempted to find previously unknown genetic factors that may influence the TAC dose requirements. The association of 105 pathway-related single...

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Identifiers

PMID: 28112181
DOI: 10.1038/aps.2016.153
PMCID: PMC5342670

Genes

CTLA4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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