Influence of Genetic Polymorphisms on Tacrolimus Pharmacokinetics in Whole Blood, Plasma, and Peripheral Blood Mononuclear Cells in Chinese Kidney Allograft Recipients.

doi:10.1097/FTD.0000000000001459

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Influence of Genetic Polymorphisms on Tacrolimus Pharmacokinetics in Whole Blood, Plasma, and Peripheral Blood Mononuclear Cells in Chinese Kidney Allograft Recipients.

Therapeutic drug monitoring - 1 Oct 2026

Lu Yun-Zhu, Lu Xiao-Ling, Wang Yu-Ping, Lu Jia-Qian, Shao Kun, An Hui-Min, Shi Hao-Qiang, Zhou Pei-Jun, Chen Bing

Abstract excerpt

BACKGROUND: Significant variations in tacrolimus (TAC) pharmacokinetics (PK) occur across whole blood, plasma, and peripheral blood mononuclear cells (PBMCs). In the present study, TAC plasma levels were estimated based on TAC whole blood levels, and the influence of genetic polymorphisms on the PKs of TAC were compared between whole blood, plasma, and PBMCs. METHODS: Whole blood, plasma, and PBMC samples of 36...

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Topics

Adult
Female
Humans
Male
Middle Aged
Young Adult

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Allografts

Area Under Curve

ATP Binding Cassette Transporter, Subfamily B

China

Cytochrome P-450 CYP3A

Genotype

Immunosuppressive Agents

Kidney Transplantation

Leukocytes, Mononuclear

Polymorphism, Genetic

Tacrolimus

Tandem Mass Spectrometry

Source

Open in PubMed

Identifiers

PMID: 41997888
DOI: 10.1097/FTD.0000000000001459

Genes

ABCB1
CYP3A5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

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