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Article

Sex differences in brain protein expression and disease.

Nature medicine - 1 Sept 2023

Wingo Aliza P, Liu Yue, Gerasimov Ekaterina S, Vattathil Selina M, Liu Jiaqi, Cutler David J, Epstein Michael P, Blokland Gabriëlla A M, Thambisetty Madhav, Troncoso Juan C, Duong Duc M, Bennett David A, Levey Allan I, Seyfried Nicholas T, Wingo Thomas S

Abstract excerpt

Most complex human traits differ by sex, but we have limited insight into the underlying mechanisms. Here, we investigated the influence of biological sex on protein expression and its genetic regulation in 1,277 human brain proteomes. We found that 13.2% (1,354) of brain proteins had sex-differentiated abundance and 1.5% (150) of proteins had sex-biased protein quantitative trait loci (sb-pQTLs). Among genes...

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Identifiers

PMID: 37653343
DOI: 10.1038/s41591-023-02509-y
PMCID: PMC10504083

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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