Article

Siglec-F Deficiency Prevents Fibrosis After Bleomycin-Induced Acute Lung Injury

2024-10-05

Abstract excerpt

Injury to the lungs causes acute inflammation that can lead to pathological lung fibrosis. Airspace macrophages (AMs) are critical for repair of injured tissue, but they can contribute fibrosis through mechanisms that are incompletely understood. Siglecs are expressed by immune cells. In mice, Siglec-F is chiefly expressed AMs where it is considered inflammosuppressive. We hypothesized that its deletion would wors...

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Literature Corpus work: 2b3a0c40-3fd4-5f5e-a07e-52172d78394e
DOI: 10.1101/2024.10.04.616703

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