Article
FLRT proteins are endogenous latrophilin ligands and regulate excitatory synapse development.
Neuron - 8 Mar 2012
O'Sullivan Matthew L, de Wit Joris, Savas Jeffrey N, Comoletti Davide, Otto-Hitt Stefanie, Yates John R, Ghosh Anirvan
Abstract excerpt
Latrophilins (LPHNs) are a small family of G protein-coupled receptors known to mediate the massive synaptic exocytosis caused by the black widow spider venom α-latrotoxin, but their endogenous ligands and function remain unclear. Mutations in LPHN3 are strongly associated with attention deficit hyperactivity disorder, suggesting a role for latrophilins in human cognitive function. Using affinity chromatography...
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