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Article

Postsynaptic adhesion GPCR latrophilin-2 mediates target recognition in entorhinal-hippocampal synapse assembly.

The Journal of cell biology - 6 Nov 2017

Anderson Garret R, Maxeiner Stephan, Sando Richard, Tsetsenis Theodoros, Malenka Robert C, Südhof Thomas C

Abstract excerpt

Synapse assembly likely requires postsynaptic target recognition by incoming presynaptic afferents. Using newly generated conditional knock-in and knockout mice, we show in this study that latrophilin-2 (Lphn2), a cell-adhesion G protein-coupled receptor and presumptive α-latrotoxin receptor, controls the numbers of a specific subset of synapses in CA1-region hippocampal neurons, suggesting that Lphn2 acts as a...

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Identifiers

PMID: 28972101
DOI: 10.1083/jcb.201703042
PMCID: PMC5674891

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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