Article
The KLB rs17618244 gene variant is associated with fibrosing MAFLD by promoting hepatic stellate cell activation.
EBioMedicine - 1 Mar 2021
Panera Nadia, Meroni Marica, Longo Miriam, Crudele Annalisa, Valenti Luca, Bellacchio Emanuele, Miele Luca, D'Oria Valentina, Paolini Erika, Maggioni Marco, Fracanzani Anna Ludovica, Alisi Anna, Dongiovanni Paola
Abstract excerpt
BACKGROUND: The rs17618244 G>A β-Klotho (KLB) variant has been associated with increased risk of ballooning and inflammation in pediatric patients with metabolic associated fatty liver disease (MAFLD), by reducing KLB expression. In hepatocytes, KLB downregulation induced fat accumulation and the expression of inflammatory and lipotoxic genes. We aimed to examine firstly the impact of the KLB rs17618244 variation...
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