Article
Bacterial-Driven Inflammation and Mutant BRAF Expression Combine to Promote Murine Colon Tumorigenesis That Is Sensitive to Immune Checkpoint Therapy.
Cancer discovery - 1 Jul 2021
DeStefano Shields Christina E, White James R, Chung Liam, Wenzel Alyssa, Hicks Jessica L, Tam Ada J, Chan June L, Dejea Christine M, Fan Hongni, Michel John, Maiuri Ashley R, Sriramkumar Shruthi, Podicheti Ram, Rusch Douglas B, Wang Hao, De Marzo Angelo M, Besharati Sepideh, Anders Robert A, Baylin Stephen B, O'Hagan Heather M, Housseau Franck, Sears Cynthia L
Abstract excerpt
Colorectal cancer is multifaceted, with subtypes defined by genetic, histologic, and immunologic features that are potentially influenced by inflammation, mutagens, and/or microbiota. Colorectal cancers with activating mutations in BRAF are associated with distinct clinical characteristics, although the pathogenesis is not well understood. The Wnt-driven multiple intestinal neoplasia (MinApcΔ716/+)...
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