Article
Colon Tumors in Enterotoxigenic Bacteroides fragilis (ETBF)-Colonized Mice Do Not Display a Unique Mutational Signature but Instead Possess Host-Dependent Alterations in the APC Gene.
Microbiology spectrum - 29 Jun 2022
Allen Jawara, Rosendahl Huber Axel, Pleguezuelos-Manzano Cayetano, Puschhof Jens, Wu Shaoguang, Wu Xinqun, Boot Charelle, Saftien Aurelia, O'Hagan Heather M, Wang Hao, van Boxtel Ruben, Clevers Hans, Sears Cynthia L
Abstract excerpt
Enterotoxigenic Bacteroides fragilis (ETBF) is consistently found at higher frequency in individuals with sporadic and hereditary colorectal cancer (CRC) and induces tumorigenesis in several mouse models of CRC. However, whether specific mutations induced by ETBF lead to colon tumor formation has not been investigated. To determine if ETBF-induced mutations impact the Apc gene, and other tumor suppressors or...
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