Article
Marked variation in prevalence of malaria-protective human genetic polymorphisms across Uganda.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Nov 2017
Walakira Andrew, Tukwasibwe Stephen, Kiggundu Moses, Verra Federica, Kakeeto Patrick, Ruhamyankaka Emmanuel, Drakeley Chris, Dorsey Grant, Kamya Moses R, Nsobya Samuel L, Rosenthal Philip J
Abstract excerpt
A number of human genetic polymorphisms are prevalent in tropical populations and appear to offer protection against symptomatic and/or severe malaria. We compared the prevalence of four polymorphisms, the sickle hemoglobin mutation (β globin E6V), the α-thalassemia 3.7kb deletion, glucose-6-phosphate dehydrogenase deficiency caused by the common African variant (G6PD A-), and the CD36 T188G mutation in 1344...
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