Article
Load-induced regulation of tendon homeostasis by SPARC, a genetic predisposition factor for tendon and ligament injuries.
Science translational medicine - 24 Feb 2021
Wang Tao, Wagner Andrea, Gehwolf Renate, Yan Wenjin, Passini Fabian S, Thien Christine, Weissenbacher Nadja, Lin Zhen, Lehner Christine, Teng Huajian, Wittner Claudia, Zheng Qiujian, Dai Jin, Ni Ming, Wang Allan, Papadimitriou John, Leys Toby, Tuan Rocky S, Senck Sasha, Snedeker Jess G, Tempfer Herbert, Jiang Qing, Zheng Ming H, Traweger Andreas
Abstract excerpt
Tendons and tendon interfaces have a very limited regenerative capacity, rendering their injuries clinically challenging to resolve. Tendons sense muscle-mediated load; however, our knowledge on how loading affects tendon structure and functional adaption remains fragmentary. Here, we provide evidence that the matricellular protein secreted protein acidic and rich in cysteine (SPARC) is critically involved in the...
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